(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

Base Information

Chemical Name:(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid
CAS No.:1439368-20-3
Molecular Formula:C₁₈H₂₅NO₆
Molecular Weight:351.4
Hs Code.:

Synonyms:(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

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Chemical Property of (2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

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Technology Process of (2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

There total 4 articles about (2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1659-31-0
2,2'-dipyridyl carbonate

: 632-20-2,134357-96-3,7013-32-3,82822-12-6
D-Threonine

: 13485-84-2
[4-(cyclohexyloxy)phenyl]methanol

: 1439368-20-3
(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

Guidance literature:: 2,2'-dipyridyl carbonate; [4-(cyclohexyloxy)phenyl]methanol; With dmap; In dichloromethane; at 20 ℃; for 15h; Inert atmosphere;

D-Threonine; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 20 ℃; for 15h;
DOI:10.1021/jm501455s

Reference yield:

: ethyl 4-(cyclohexyloxy)benzoate

: 1439368-20-3
(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

2.2: 15 h / 20 °C

With dmap; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1439368-20-3
(2R,3S)-2-[({[4-(cyclohexyloxy)phenyl]methoxy}carbonyl)amino]-3-hydroxybutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / 2 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

3.1: dmap / dichloromethane / 15 h / 20 °C / Inert atmosphere

3.2: 15 h / 20 °C

With dmap; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; In tetrahydrofuran; dichloromethane;