1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

Base Information

Chemical Name:1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone
CAS No.:862658-64-8
Molecular Formula:C₂₃H₃₂O₃Si
Molecular Weight:384.591
Hs Code.:

Synonyms:1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

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Chemical Property of 1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

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Technology Process of 1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

There total 6 articles about 1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 862658-52-4
1-[2-(5-hydroxy-4-methoxy-hepta-1,6-diynyl)-4-methyl-phenyl]-ethanone

: 18162-48-6
tert-butyldimethylsilyl chloride

: 862658-64-8
1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/jo050400a

Reference yield:

: 4-methoxy-1-trimethylsilanyl-hepta-1,6-diyn-3-ol

: 862658-64-8
1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / PdCl₂(PPh₃)2; CuI / 5 h / 80 °C

2: 304 mg / n-Bu₄NF / tetrahydrofuran / 2.5 h / 20 °C

3: 90 percent / imidazole / dimethylformamide

With 1H-imidazole; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Sonogashira reaction;
DOI:10.1021/jo050400a

Reference yield:

: 862658-60-4
2-methoxypent-4-ynal

: 862658-64-8
1-{2-[5-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-hepta-1,6-diynyl]-4-methyl-phenyl}-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 58 percent / tetrahydrofuran; hexane / -78 - 20 °C

2.1: triethylamine / PdCl₂(PPh₃)2; CuI / 5 h / 80 °C

3.1: 304 mg / n-Bu₄NF / tetrahydrofuran / 2.5 h / 20 °C

4.1: 90 percent / imidazole / dimethylformamide

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 2.1: Sonogashira reaction;
DOI:10.1021/jo050400a