1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

Base Information

Chemical Name:1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate
CAS No.:1229246-08-5
Molecular Formula:C₁₉H₂₄Cl₂N₂O₂
Molecular Weight:383.318
Hs Code.:

Synonyms:1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

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Chemical Property of 1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

Chemical Property:

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Technology Process of 1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

There total 10 articles about 1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1229246-13-2
1,1-dimethylethyl cyclopropyl({2,3-dichloro-5-[(2E)-3-cyano-2-propen-1-yl]phenyl}-methyl)carbamate

: 1229246-08-5
1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 1.5h;

Reference yield:

: 1229246-37-0
5-bromo-2,3-dichlorobenzaldehyde

: 1229246-08-5
1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: magnesium sulfate / dichloromethane / 20 °C

2.1: magnesium sulfate / dichloromethane / 20 °C

3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 48 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

5.1: sodium carbonate; triphenylphosphine / palladium diacetate / propan-1-ol; water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere of nitrogen

6.1: 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 12 h / 20 °C

6.2: 12 h / 20 °C

7.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0 - 20 °C

8.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / tetrahydrofuran / 0.25 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

With sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; sodium carbonate; magnesium sulfate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; lithium chloride; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;

Reference yield:

: C₁₀H₈BrCl₂N

: 1229246-08-5
1,1-dimethylethyl cyclopropyl{[2,3-dichloro-5-(3-cyanopropyl)phenyl]-methyl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 48 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

3.1: sodium carbonate; triphenylphosphine / palladium diacetate / propan-1-ol; water; N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere of nitrogen

4.1: 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane / bis(1,5-cyclooctadiene)diiridium(I) dichloride / tetrahydrofuran / 12 h / 20 °C

4.2: 12 h / 20 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 0 - 20 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride / tetrahydrofuran / 0.25 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

With sodium tetrahydroborate; hydrogen; sodium hydrogencarbonate; sodium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; 1,4-di(diphenylphosphino)-butane; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; lithium chloride; bis(1,5-cyclooctadiene)diiridium(I) dichloride; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; propan-1-ol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;