(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Base Information

Chemical Name:(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate
CAS No.:1335286-71-9
Molecular Formula:C₄₂H₅₇NO₈Si
Molecular Weight:732.002
Hs Code.:

(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Synonyms:(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Suppliers and Price of (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

There total 17 articles about (S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1335286-70-8
(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-tert-butyldiphenylsilyloxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

: 1335286-71-9
(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Guidance literature:: With water; acetic acid; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: ethyl (2E,4S,5S)-5-((tert-butyldimethylsilyl)oxy)-4-hydroxy-2-hexenoate

: 1335286-71-9
(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; benzene / 2 h / 0 - 20 °C / Inert atmosphere

2.1: methanol; ammonia / water / 3 h / 0 - 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 2 h / 0 - 20 °C

4.2: pH 3 - 4

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 °C / Inert atmosphere

6.1: water; acetic acid / tetrahydrofuran / Inert atmosphere

With methanol; dmap; ammonia; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; toluene; benzene;
DOI:10.1016/j.tet.2011.08.014

Reference yield:

: 1335286-68-4
N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methyl-3-butenyl]-(S)-3-tert-butyldimethylsilyloxy-butanamide

: 1335286-71-9
(S)-3-{N-benzyl-N-[(1R,2S)-2-tert-butyldiphenylsilyloxy-1-methylbutenyl]amino}-1-methyl-3-oxo-propyl (2E,4R,5S)-5-hydroxy-4-(2-methoxyethoxy)methoxy-2-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 °C / Inert atmosphere

3: water; acetic acid / tetrahydrofuran / Inert atmosphere

With dmap; tetrabutyl ammonium fluoride; water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.08.014