2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine
• CAS No.: 1201687-89-9
• Molecular Formula: C₈H₉ClN₄
• Molecular Weight: 196.639
• Mol file: 1201687-89-9.mol

Synonyms:2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

Chemical Property of 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

Chemical Property:

• Density: 1.43±0.1 g/cm3(Predicted)

Purity/Quality:

2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

There total 7 articles about 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(5,7-dimethyl- [1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol (54535-00-1) → 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine (1201687-89-9)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2018.04.029

Reference yield: 9.0%

1-amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-amnnoniunn 2,4,6-trinnethyl-benzenesulfonate (446839-32-3) + methyl chloroacetate (96-34-4) → 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine (1201687-89-9)

Guidance literature:

1-amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-amnnoniunn 2,4,6-trinnethyl-benzenesulfonate; With sodium hydroxide; In ethanol; at 50 - 60 ℃; for 1h;

methyl chloroacetate; In ethanol; for 4h; Reflux;

Reference yield: 9.0%

2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8) + 1-amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-amnnoniunn 2,4,6-trinnethyl-benzenesulfonate (446839-32-3) + hydroxylamine-O-mesitylenesulfonic acid + methyl chloroacetate (96-34-4) → 2-(chloromethyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine (1201687-89-9)

Guidance literature:

With NaOH; In ethanol; dichloromethane;

upstream raw materials:

1-amino-4,6-dimethyl-1H-pyrimidin-2-ylidene-amnnoniunn 2,4,6-trinnethyl-benzenesulfonate

methyl chloroacetate

2-Amino-4,6-dimethylpyrimidine

5,7-dimethyl-1,2,4-triazolo<1,5-a>pyrimidine-2-carboxylic acid

Downstream raw materials:

2,5,7-Trimethyl-s-triazolo<1,5-a>pyrimidin