2-Amino-4,6-dimethylpyrimidine

Base Information

• Chemical Name: 2-Amino-4,6-dimethylpyrimidine
• CAS No.: 767-15-7
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 29335995
• European Community (EC) Number: 212-181-5
• NSC Number: 3278
• UNII: 4S48MI253M
• DSSTox Substance ID: DTXSID8052510
• Nikkaji Number: J96E
• Wikidata: Q27260417
• ChEMBL ID: CHEMBL4546836
• Mol file: 767-15-7.mol

Synonyms:2-ADMP;2-amino-4,6-dimethyl pyrimidine

Chemical Property of 2-Amino-4,6-dimethylpyrimidine

Chemical Property:

• Appearance/Colour: White crystalline powder
• Vapor Pressure: 0.00166mmHg at 25°C
• Melting Point: 151-153 °C(lit.)
• Refractive Index: 1.569
• Boiling Point: 294 °C at 760 mmHg
• PKA: 5.11±0.10(Predicted)
• Flash Point: 156.7 °C
• PSA: 51.80000
• Density: 1.112 g/cm³
• LogP: 1.25680
• Storage Temp.: Store below +30°C.
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.3

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-4,6-dimethylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)N)C
• Uses: 2-Amino-4,6-dimethylpyrimidine is a bioactive compound.

Technology Process of 2-Amino-4,6-dimethylpyrimidine

There total 35 articles about 2-Amino-4,6-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

guanidine nitrate (506-93-4) + acetylacetone (123-54-6,81235-32-7) → 2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8)

Guidance literature:

With potassium carbonate; In water; at 80 ℃; for 7h;

DOI:10.1016/j.bmc.2018.04.029

Reference yield: 96.0%

guanidine hydrochloride (50-01-1) + acetylacetone (123-54-6,81235-32-7) → 2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8)

Guidance literature:

With potassium carbonate; for 0.0833333h; microwave irradiation;

DOI:10.1071/CH06388

Reference yield: 95.0%

guanidinium sulfate (646-34-4,1184-68-5) + acetylacetone (123-54-6,81235-32-7) → 2-Amino-4,6-dimethylpyrimidine (767-15-7,184433-59-8)

Guidance literature:

With sodium carbonate; In water; at 100 ℃; Inert atmosphere;

DOI:10.1021/ml200095w

upstream raw materials:

2-chloro-4,6-dimethylpyrimidine

sulfadimesine

guanidine hydrogen carbonate

acetylacetone

Downstream raw materials:

4-hydroxy-benzenesulfonic acid-(4,6-dimethyl-pyrimidin-2-ylamide)

2-Acetamido-4,6-dimethylpyrimidin

N-(4,6-dimethyl-pyrimidin-2-yl)-N'-(toluene-4-sulfonyl)-urea

N-benzyl-2-amino-4,6-dimethylpyrimidine

Refernces

• 1、 Bayramo?lu, Duygu,Kurtay, Gülbin,Güllü, Mustafa. "Ultrasound-assisted rapid synthesis of 2-aminopyrimidine and barbituric acid derivatives". . p. 649 - 658. Retrieved 2020/02/11.
• 2、 Ignatovich, Zh. V.,Ermolinskaya,Petushok,Katok, Ya. M.,Koroleva. "Synthesis of 4,4′-Oxydibenzoic Acid Amides and Sulfonamides Containing 2-Arylaminopyrimidine Moieties". . p. 2092 - 2097. Retrieved 2021/02/09.