diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

Base Information

Chemical Name:diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate
CAS No.:1391621-94-5
Molecular Formula:C₃₁H₃₉N₃O₆S₂
Molecular Weight:613.799
Hs Code.:

Synonyms:diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

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Chemical Property of diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

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Technology Process of diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

There total 10 articles about diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1391622-88-0
3-amino-N-(2-(propylthio)benzo[d]thiazol-6-yl)propanamide

: 1370290-52-0
4-(4-(3-ethoxy-2-(ethoxycarbonyl)-3-oxopropyl)phenyl)butanoic acid

: 1391621-94-5
diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 22 ℃; for 16h;
DOI:10.1021/jm201734r

Reference yield:

: 10031-93-3
ethyl 4-phenylbutyrate

: 1391621-94-5
diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 16 h / 22 - 80 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C

2.2: Sonication

3.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C

3.2: 16 h / 22 °C

4.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve

4.2: 16 h / 22 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 22 °C

With 1H-imidazole; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Duff reaction / 4.1: Knoevenagel condensation;
DOI:10.1021/jm201734r

Reference yield:

: 1821-12-1
4-Phenylbutyric acid

: 1391621-94-5
diethyl 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 20 h / Reflux

2.1: trifluoroacetic acid / 16 h / 22 - 80 °C

3.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C

3.2: Sonication

4.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C

4.2: 16 h / 22 °C

5.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve

5.2: 16 h / 22 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 22 °C

With 1H-imidazole; lithium hydroxide monohydrate; sulfuric acid; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: Duff reaction / 5.1: Knoevenagel condensation;
DOI:10.1021/jm201734r