Technology Process of 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonic acid
There total 12 articles about 2-(4-(4-oxo-4-(3-oxo-3-(2-(propylthio)benzo[d]thiazol-6-ylamino)propylamino)butyl)benzyl)malonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trifluoroacetic acid / 16 h / 22 - 80 °C
2.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C
2.2: Sonication
3.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C
3.2: 16 h / 22 °C
4.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve
4.2: 16 h / 22 °C
5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 22 °C
6.1: water; sodium hydroxide / tetrahydrofuran / 16 h / 22 °C
7.1: water; sodium hydroxide / 4 h / 80 °C
With
1H-imidazole; lithium hydroxide monohydrate; water; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
1.1: Duff reaction / 4.1: Knoevenagel condensation;
DOI:10.1021/jm201734r
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sulfuric acid / 20 h / Reflux
2.1: trifluoroacetic acid / 16 h / 22 - 80 °C
3.1: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water / 16 h / 22 °C
3.2: Sonication
4.1: 1H-imidazole; 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 22 °C
4.2: 16 h / 22 °C
5.1: polymer-supported trisamine resin / toluene / 40 h / 50 - 60 °C / Molecular sieve
5.2: 16 h / 22 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 22 °C
7.1: water; sodium hydroxide / tetrahydrofuran / 16 h / 22 °C
8.1: water; sodium hydroxide / 4 h / 80 °C
With
1H-imidazole; lithium hydroxide monohydrate; sulfuric acid; water; N-ethyl-N,N-diisopropylamine; HATU; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
2.1: Duff reaction / 5.1: Knoevenagel condensation;
DOI:10.1021/jm201734r
- Guidance literature:
-
With
water; sodium hydroxide;
at 80 ℃;
for 4h;
DOI:10.1021/jm201734r
