(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

Base Information

Chemical Name:(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol
CAS No.:85593-72-2
Molecular Formula:C₄₆H₆₀O₃Si₂
Molecular Weight:717.152
Hs Code.:

Synonyms:(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

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Chemical Property of (2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

Chemical Property:

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Technology Process of (2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

There total 10 articles about (2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 85593-71-1
(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trienoic acid ethyl ester

: 85593-72-2
(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

Guidance literature:: With aluminium hydride; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(00)85704-4

Reference yield:

: 53036-80-9
6-carboxy hexylidene triphenylphosphorane

: 85593-72-2
(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 °C

2: 80 percent / LiAlH₄ / tetrahydrofuran / Heating

3: TFA / tetrahydrofuran; H₂O / 16 h / Ambient temperature

5: 50 percent / benzene / 6 h / 80 °C

6: 80 percent / DMAP, Et₃N / CH₂Cl₂

7: 90 percent / NaH / toluene

8: 90 percent / AlH₃ / tetrahydrofuran / 0 °C

With aluminium hydride; dmap; lithium aluminium tetrahydride; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; toluene; benzene;
DOI:10.1016/S0040-4039(00)85704-4

Reference yield:

: 85593-68-6
(Z)-(R)-2-(tert-Butyl-diphenyl-silanyloxy)-10-hydroxy-dec-4-enal

: 85593-72-2
(2E,4E,8Z)-(R)-6,14-Bis-(tert-butyl-diphenyl-silanyloxy)-tetradeca-2,4,8-trien-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / benzene / 6 h / 80 °C

2: 80 percent / DMAP, Et₃N / CH₂Cl₂

3: 90 percent / NaH / toluene

4: 90 percent / AlH₃ / tetrahydrofuran / 0 °C

With aluminium hydride; dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; benzene;
DOI:10.1016/S0040-4039(00)85704-4