2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline

Base Information

• Chemical Name: 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline
• CAS No.: 1023306-55-9
• Molecular Formula: C₁₉H₁₂F₃N
• Molecular Weight: 311.306
• Mol file: 1023306-55-9.mol

Synonyms:2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline

Chemical Property of 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline

There total 1 articles about 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-(6-trimethylsilyl-3(Z)-hexen-1,5-diynyl)aniline (1023306-51-5) + m-trifluoromethylphenyl iodide (401-81-0) → 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline (1023306-55-9)

Guidance literature:

With potassium carbonate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; at 20 ℃; for 6h;

DOI:10.1021/jm070820n

Reference yield: 90.0%

2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline (1023306-55-9) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)acetamide (1198748-17-2)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2009.09.042

Reference yield: 89.0%

5-bromovaleroyl chloride (4509-90-4) + 2-(6-(2-trifluoromethylphenyl)-3(Z)-hexen-1,5-diynyl)aniline (1023306-55-9) → 5-bromo-N-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)pentanamide (1198748-20-7)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.bmc.2009.09.042

upstream raw materials:

2-(6-trimethylsilyl-3(Z)-hexen-1,5-diynyl)aniline

m-trifluoromethylphenyl iodide

Downstream raw materials:

4-bromo-N-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)butanamide

5-bromo-N-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)pentanamide

N-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)propionamide

N-(2-((Z)-6-(2-(trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)benzamide