(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

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Chemical Name:(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester
CAS No.:129460-84-0
Molecular Formula:C₃₅H₄₀N₄O₉
Molecular Weight:660.724
Hs Code.:

(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

Synonyms:(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

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Chemical Property of (S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

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Technology Process of (S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

There total 3 articles about (S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 42854-62-6
L-alanine benzyl ester p-toluenesulfonate

: 123126-84-1
N-acetyl-L-tyrosyl-L-aspartic acid

: 129460-84-0
(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; for 10h;
DOI:10.1016/0008-6215(90)84295-6

Reference yield:

: 537-55-3
N-acetyl-L-tyrosine

: 129460-84-0
(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / triethylamine, EEDQ / 24 h / Ambient temperature

2: H₂ / 10percent Pd-C / ethanol; aq. acetic acid / Ambient temperature

3: 67 percent / EDAC, HOBT / 10 h

With hydrogen; benzotriazol-1-ol; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1016/0008-6215(90)84295-6

Reference yield:

: 129472-24-8
dibenzyl N-acetyl-L-tyrosyl-L-aspartate

: 129460-84-0
(S)-2-[(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-3-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-propionylamino]-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd-C / ethanol; aq. acetic acid / Ambient temperature

2: 67 percent / EDAC, HOBT / 10 h

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; acetic acid;
DOI:10.1016/0008-6215(90)84295-6