(2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine

Base Information

• Chemical Name: (2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine
• CAS No.: 1416475-19-8
• Molecular Formula: C₃₁H₃₄BrNO₆
• Molecular Weight: 596.518

Synonyms:(2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine

Chemical Property of (2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine

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Technology Process of (2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine

There total 1 articles about (2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

5-(4-bromophenyl)-4-tert-butoxycarbonyl-2-methoxycarbonylpyrrolidine + (S)-naproxenoyl chloride (51091-84-0) → (2R,4R,5S)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine (1416475-19-8) + (2S,4S,5R)-5-(4-bromophenyl)-4-tert-butoxy-carbonyl-1-[(2'S)-2'-(6''-methoxynaphth-2''-yl)propionyl]-2-methoxy-carbonylpyrrolidine (1416475-24-5)

Guidance literature:

With N,N-diethylaniline; In dichloromethane; at 20 ℃; for 6h; Solvent; diastereoselective reaction; Resolution of racemate;

DOI:10.1016/j.tetasy.2012.10.020

upstream raw materials:

(S)-naproxenoyl chloride

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