51091-84-0Relevant articles and documents
Non-carboxylic Analogues of Aryl Propionic Acid: Synthesis, Anti-inflammatory, Analgesic, Antipyretic and Ulcerogenic Potential
Eissa,Farrag,Galeel
, p. 485 - 492 (2014)
As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was efficiently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-inflammatory activities using carrageenin-induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic effects. Among the synthesized compounds, thiourea derivative (6a, e) exhibited higher anti-inflammatory activity than the standard drug naproxen in reduction of the rat paw edema (88.71, 89.77%) respectively. All of the non-carboxylic tested compounds were found to have promising anti-inflammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic effects.
Chiral lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reactions of nitrogen-stabilized oxyallyl cations derived from allenamides
Huang, Jian,Hsung, Richard P.
, p. 50 - 51 (2005)
A chiral Lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reaction of allenamide-derived nitrogen-stabilized chiral oxyallyl cations is described here. The use of bisoxazoline ligand and CuOTf2 provides high enantioselectivity, especially with [SbF6]- as the counteranion. Copyright
S-(+)-naproxen chloride as acylating agent for separating the enantiomers of chiral amines and alcohols
Spahn
, p. 847 - 850 (1988)
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Esterase-activated release of naproxen from supramolecular nanofibres
Conda-Sheridan, Martin,Lee, Sungsoo S.,Preslar, Adam T.,Stupp, Samuel I.
, p. 13757 - 13760 (2014)
Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained. This journal is
Practical and sustainable approach for clean preparation of 5-organylselanyl uracils
Chen, Jin-Yang,Zhong, Chun-Tao,Gui, Qing-Wen,Zhou, Yuan-Ming,Fang, Yang-Yang,Liu, Kai-Jian,Lin, Ying-Wu,Cao, Zhong,He, Wei-Min
supporting information, p. 475 - 479 (2020/10/12)
An eco-friendly, sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and diorganyl diselenides at room temperature under oxidant- and external electrolyte-free cond
Visible-Light-Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to gem-Difluoroallylboranes
Chen, Guojun,Wang, Liling,Liu, Xiaozu,Liu, Peijun
supporting information, p. 2990 - 2996 (2020/06/10)
A photoredox-catalyzed defluoroborylation of trifluoromethyl alkenes with N-heterocyclic carbene boranes is described for the synthesis of gem-difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables the late-stage functionalization of structurally complex compounds. Further transformations of the defluoroborylation products to valuable CF2-containing molecules are also demonstrated. (Figure presented.).