pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

Base Information

Chemical Name:pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate
CAS No.:639482-11-4
Molecular Formula:C₂₇H₁₄F₆N₂O₃S
Molecular Weight:560.476
Hs Code.:

Synonyms:pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

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Chemical Property of pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

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Technology Process of pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

There total 9 articles about pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 816424-65-4
lithium 3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 639482-11-4
pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: lithium 3-[(4-fluoro-3-methylphenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

2,3,4,5,6-pentafluorophenol; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

Reference yield:

: 639482-10-3
ammonium 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 639482-11-4
pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: ammonium 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

2,3,4,5,6-pentafluorophenol; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

Reference yield:

: 72832-23-6
ethyl 3-bromothieno(2,3-b)pyridine-2-carboxylate

: 639482-11-4
pentafluorophenyl 3-[(4-fluoro-3-methylphenyl)amino]-7-phenyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18.5 h / 20 °C

1.2: pH 8.5

2.1: trifluoroacetic anhydride / DMF (N,N-dimethyl-formamide) / 1.25 h / 20 °C

3.1: pyridine; copper diacetate / dichloromethane / 18 h / 20 °C

4.1: / toluene / 0.08 h

4.2: 24 h / Heating / reflux

5.1: lithium hydroxide; ethanol; water / tetrahydrofuran / 80 °C

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

6.2: 24 h / 20 °C

With pyridine; lithium hydroxide; ethanol; water; copper diacetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); dichloromethane; toluene;