Ethyl 3-broMothieno[2,3-b]pyridine-2-carboxylate

Base Information

• Chemical Name: Ethyl 3-broMothieno[2,3-b]pyridine-2-carboxylate
• CAS No.: 72832-23-6
• Molecular Formula: C₁₀H₈BrNO₂S
• Molecular Weight: 286.149
• Hs Code.: 2934999090
• Mol file: 72832-23-6.mol

Synonyms:3-Bromo-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester;

Chemical Property of Ethyl 3-broMothieno[2,3-b]pyridine-2-carboxylate

Chemical Property:

• Vapor Pressure: 7.88E-06mmHg at 25°C
• PSA: 67.43000
• LogP: 3.23550
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-thieno[2,3-b]pyridine-2-carboxylicacidethylester 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3-broMothieno[2,3-b]pyridine-2-carboxylate

There total 3 articles about Ethyl 3-broMothieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate (52505-46-1) → ethyl 3-bromothieno(2,3-b)pyridine-2-carboxylate (72832-23-6)

Guidance literature:

ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate; With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 20 - 25 ℃; for 2h;

With hydrogenchloride; In water; acetonitrile;

Reference yield: 72.0%

→ ethyl 3-bromothieno(2,3-b)pyridine-2-carboxylate (72832-23-6)

Guidance literature:

Reference yield:

2-chloro-3-pyridinecarbonitrile (6602-54-6) → ethyl 3-bromothieno(2,3-b)pyridine-2-carboxylate (72832-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; water / 1,2-dimethoxyethane / 1 h / -5 - 0 °C / Inert atmosphere

2: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 2 h / 65 °C / Inert atmosphere

With tert.-butylnitrite; water; potassium hydroxide; copper(ll) bromide; In 1,2-dimethoxyethane; acetonitrile;

DOI:10.1021/jm400043d

upstream raw materials:

ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate

2-chloro-3-pyridinecarbonitrile

Downstream raw materials:

3-bromothieno(2,3-b)pyridine-2-carboxylic acid

3-bromo-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylic acid

ethyl 3-bromo-7-(4-methylphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-2-carboxylate

Refernces

• 1、 -. "INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES". Page/Page column 80-81. . Retrieved 2012/10/18.
• 2、 -. "HETEROCYCLIC COMPOUND". Page/Page column 43. . Retrieved 2009/12/07.