(1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane

Base Information

• Chemical Name: (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane
• CAS No.: 1158373-47-7
• Molecular Formula: C₃₅H₂₆N₂O₄S₂
• Molecular Weight: 602.734
• Mol file: 1158373-47-7.mol

Synonyms:(1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane

Chemical Property of (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane

There total 6 articles about (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-benzenesulfonyl-1H-indol-2-yl)phenyl]methanol (1158373-44-4) → (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane (1158373-47-7)

Guidance literature:

(1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-benzenesulfonyl-1H-indol-2-yl)phenyl]methanol; With triethylsilane; In dichloromethane; for 0.5h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

(1-(phenylsulfonyl)-1H-indol-2-yl)boronic acid → (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane (1158373-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane

2: lithium diisopropyl amide / tetrahydrofuran / -78 °C

3: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

With triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 1: Suzuki coupling;

DOI:10.1007/s00280-010-1319-8

Reference yield:

1-benzenesulfonylindole (40899-71-6) → (1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-Benzenesulfonyl-1H-indol-2-yl)phenyl]methane (1158373-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium diisopropyl amide / tetrahydrofuran / -78 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane

3: lithium diisopropyl amide / tetrahydrofuran / -78 °C

4: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

With triethylsilane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; 2: Suzuki coupling;

DOI:10.1007/s00280-010-1319-8

upstream raw materials:

(1-benzenesulfonyl-1H-indol-2-yl)-[3-(1-benzenesulfonyl-1H-indol-2-yl)phenyl]methanol

1-benzenesulfonylindole

3-(1-benzenesulfonyl-1H-indol-2-yl)-benzaldehyde

m-iodobenzaldehyde