t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

Base Information

Chemical Name:t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate
CAS No.:147290-99-1
Molecular Formula:C₃₂H₃₅N₅O₆
Molecular Weight:585.66
Hs Code.:

Synonyms:t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

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Chemical Property of t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

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Technology Process of t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

There total 7 articles about t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 147290-45-7
4-benzoic acid

: 147290-98-0
tert-butyl 7-amino-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-2-propanoate

: 147290-99-1
t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm980166z

Reference yield:

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 147290-99-1
t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / NaOAc, NaBH₃CN / methanol / 2 h / Ambient temperature

2: Et₃N, BOP / CH₂Cl₂ / Ambient temperature

3: 4M aq. HCl / CH₂Cl₂; dioxane / 3 h / 0 °C

4: 18 percent / Et₃N, DMSO / H₂O

5: 98 percent / H₂ / PtO₂ / ethyl acetate / 1 h / 2068.59 Torr

6: 4 percent / BOP, Et₃N / dimethylformamide

With hydrogenchloride; hydrogen; sodium acetate; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dimethyl sulfoxide; triethylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980166z

Reference yield:

: 15231-41-1
tert-butyl 3-aminopropanoate

: 147290-99-1
t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / NaOAc, NaBH₃CN / methanol / 2 h / Ambient temperature

2: Et₃N, BOP / CH₂Cl₂ / Ambient temperature

3: 4M aq. HCl / CH₂Cl₂; dioxane / 3 h / 0 °C

4: 18 percent / Et₃N, DMSO / H₂O

5: 98 percent / H₂ / PtO₂ / ethyl acetate / 1 h / 2068.59 Torr

6: 4 percent / BOP, Et₃N / dimethylformamide

With hydrogenchloride; hydrogen; sodium acetate; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dimethyl sulfoxide; triethylamine; platinum(IV) oxide; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm980166z