N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

Base Information

Chemical Name:N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine
CAS No.:1427549-74-3
Molecular Formula:C₂₈H₂₉FN₄O₄
Molecular Weight:504.561
Hs Code.:

Synonyms:N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

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Chemical Property of N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

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Technology Process of N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

There total 9 articles about N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427549-73-2
methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

: 1427549-74-3
N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 60 ℃; for 2h;

Reference yield:

: 1427549-89-0
3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-carboxylic acid

: 1427549-74-3
N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1427549-83-4
methyl 3-cyclohexyl-2-(4-fluorophenyl)-1H-imidazo[1,2-b]pyrazole-6-carboxylate

: 1427549-74-3
N-{[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-yl]carbonyl}-L-tyrosine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;