methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

Base Information

Chemical Name:methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate
CAS No.:1427549-73-2
Molecular Formula:C₂₉H₃₁FN₄O₄
Molecular Weight:518.588
Hs Code.:

Synonyms:methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

There total 8 articles about methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1427549-89-0
3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-1H-imidazo[1,2-b]pyrazole-6-carboxylic acid

: 3417-91-2
L-tyrosine methyl ester HCl

: 1427549-73-2
methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1427549-83-4
methyl 3-cyclohexyl-2-(4-fluorophenyl)-1H-imidazo[1,2-b]pyrazole-6-carboxylate

: 1427549-73-2
methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1427549-87-8
methyl 3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carboxylate

: 1427549-73-2
methyl (2S)-2-[[3-cyclohexyl-2-(4-fluorophenyl)-1-methyl-imidazo[1,2-b]pyrazole-6-carbonyl]amino]-3-(4-hydroxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 60 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;