N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester
CAS No.:115141-31-6
Molecular Formula:C₃₁H₄₃N₃O₇
Molecular Weight:569.698
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

There total 1 articles about N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 33014-68-5
tert-butoxycarbonyl-L-phenylalanyl-L-leucine

: 86088-59-7
L-threonine benzyl ester hemioxalate

: 115141-31-6
N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In chloroform; 0 Degc, 0.5 h; RT, overnight;
DOI:10.1021/jm00118a005

Reference yield: 99.0%

: 115141-31-6
N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

: 114414-66-3
H-Phe-Leu-Thr-OCH₂C₆H₅

Guidance literature:: In trifluoroacetic acid; 0 deg C, 30 min; RT, 50 min;
DOI:10.1021/jm00118a005

Reference yield:

: 115141-31-6
N-(tert-butyloxycarbonyl)-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

: 111035-56-4
Tyr-D-Ser(O-t-Bu)-Gly-Phe-Leu-Thr

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / trifluoroacetic acid / 0 deg C, 30 min; RT, 50 min

2: 90 percent / 1-hydroxybenzotriazole, DCC / tetrahydrofuran; triethylamine; CHCl₃ / 0 deg C, 1 h; RT, overnight

3: 85 percent / H₂ / 10percent Pd/C / methanol / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform; triethylamine; trifluoroacetic acid;
DOI:10.1021/jm00118a005