2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI)

Base Information

Chemical Name:2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI)
CAS No.:386766-72-9
Molecular Formula:C₈H₁₇NO₂
Molecular Weight:159.228
Hs Code.:
Mol file:386766-72-9.mol

Synonyms:2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI)

Suppliers and Price of 2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI)

Chemical Property:

PSA：43.70000
LogP:-0.23820

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI)

There total 5 articles about 2-Pyrrolidinemethanol, 2-ethyl-4-hydroxy-1-methyl-, (2R,4R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 386766-62-7
4-(tert-butyl-diphenyl-silanyloxy)-2-ethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 386766-72-9
(3R,5R)-5-Ethyl-5-hydroxymethyl-1-methyl-pyrrolidin-3-ol

: 386766-63-8
[(2S,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-1-methyl-pyrrolidin-2-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1055/s-2001-17454

Reference yield:

: 1499-56-5,775275-31-5,790644-51-8,754962-86-2
(R)-4-hydroxy-L-proline ethyl ester

: 386766-72-9
(3R,5R)-5-Ethyl-5-hydroxymethyl-1-methyl-pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: Et₃N / dioxane; H₂O / 24 h / 20 °C

2.1: imidazole / dimethylformamide / 48 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: HMPA / tetrahydrofuran / 0.33 h / -78 °C

4.1: LAH / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; lithium aluminium tetrahydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-17454

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 386766-72-9
(3R,5R)-5-Ethyl-5-hydroxymethyl-1-methyl-pyrrolidin-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 48 h / 20 °C

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: HMPA / tetrahydrofuran / 0.33 h / -78 °C

3.1: LAH / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1055/s-2001-17454