ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

Base Information

Chemical Name:ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate
CAS No.:198064-67-4
Molecular Formula:C₂₀H₂₂ClN₃O₃
Molecular Weight:387.866
Hs Code.:

Synonyms:ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

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Chemical Property of ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

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Technology Process of ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

There total 8 articles about ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 693-98-1
2-methylimidazole

: 198064-65-2
ethyl 5-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]pentanoate

: 198064-67-4
ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 - 130 ℃; for 2h;
DOI:10.1248/cpb.51.565

Reference yield:

: 14794-32-2
ethyl 6-(chloroformyl)hexanoate

: 198064-67-4
ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / AlCl₃ / 20 °C

2: Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / Heating

4: pyridine / tetrahydrofuran / 20 °C

5: 71 percent / NH₄OAc; AcOH / Heating

6: 78 percent / POCl₃; pyridine / 125 °C

7: 88 percent / K₂CO₃ / dimethylformamide / 2 h / 120 - 130 °C

With pyridine; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1248/cpb.51.565

Reference yield:

: 108-90-7
chlorobenzene

: 198064-67-4
ethyl 5-[4-(4-chlorophenyl)-2-(2-methyl-1H-imidazol-1-yl)-5-oxazolyl]pentanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / AlCl₃ / 20 °C

2: Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / Heating

4: pyridine / tetrahydrofuran / 20 °C

5: 71 percent / NH₄OAc; AcOH / Heating

6: 78 percent / POCl₃; pyridine / 125 °C

7: 88 percent / K₂CO₃ / dimethylformamide / 2 h / 120 - 130 °C

With pyridine; aluminium trichloride; ammonium acetate; bromine; sodium formate; potassium carbonate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Friedel-Crafts reaction;
DOI:10.1248/cpb.51.565