2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

Base Information

Chemical Name:2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate
CAS No.:70822-11-6
Molecular Formula:C₂₁H₂₅NO₉S
Molecular Weight:467.497
Hs Code.:

Synonyms:2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

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Chemical Property of 2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

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Technology Process of 2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

There total 4 articles about 2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 70822-23-0
1-<(2-hydroxyethoxy)methyl>-1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepin

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 70822-11-6
2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

Guidance literature:: With triethylamine; In toluene; at 20 - 50 ℃; for 2h;
DOI:10.1021/jm00183a019

Reference yield:

: 3929-47-3
3-(3,4-dimethoxyphenyl)-1-propanol

: 70822-11-6
2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 34 percent / TFA / nitromethane / 3.5 h / 65 °C

2: 89 percent / diisopropylethylamine / 7 h / 100 °C

3: 32 percent / Et₃N / toluene / 2 h / 20 - 50 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In nitromethane; toluene;
DOI:10.1021/jm00183a019

Reference yield:

: 2107-70-2
3,4-methoxycinnamic acid

: 70822-11-6
2-[(1,3,4,5-tetrahydro-7,8-dimethoxy-2-benzoxepine-1-yl)methoxy]ethyl-4-nitrobenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / BH₃*Me₂S / CH₂Cl₂ / 1 h / Ambient temperature

2: 34 percent / TFA / nitromethane / 3.5 h / 65 °C

3: 89 percent / diisopropylethylamine / 7 h / 100 °C

4: 32 percent / Et₃N / toluene / 2 h / 20 - 50 °C

With dimethylsulfide borane complex; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In nitromethane; dichloromethane; toluene;
DOI:10.1021/jm00183a019