N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester

Base Information

• Chemical Name: N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester
• CAS No.: 92264-96-5
• Molecular Formula: C₂₃H₂₉N₂O₁₀P
• Molecular Weight: 524.464
• Mol file: 92264-96-5.mol

Synonyms:N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester

Chemical Property of N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester

There total 2 articles about N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(tert-butoxycarbonyl)-L-tyrosyl p-nitrobenzyl ester (92264-95-4) + Dimethyl chlorophosphate (813-77-4) → N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester (92264-96-5)

Guidance literature:

With sodium hydride; 1) dioxan, 10-15 deg C, 30 min, 2) 1h, room temp.;

DOI:10.1016/S0040-4039(01)81243-0

Reference yield: 60.9%

N-(tert-butoxycarbonyl)-L-tyrosyl p-nitrobenzyl ester (92264-95-4) + Dimethyl phosphite (868-85-9) → N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester (92264-96-5)

Guidance literature:

With triethylamine; In tetrachloromethane; ethyl acetate; at 23 ℃; for 24h;

DOI:10.1021/jo00087a025

Reference yield: 98.0%

N-(tert-Butoxycarbonyl)-O-(dimethylphosphono)-L-tyrosyl p-nitrobenzyl ester (92264-96-5) → Nα-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine (92264-99-8)

Guidance literature:

With hydrogen; palladium; In methanol; acetic acid;

DOI:10.1016/S0040-4039(01)81243-0

upstream raw materials:

N-(tert-butoxycarbonyl)-L-tyrosyl p-nitrobenzyl ester

Dimethyl phosphite

Dimethyl chlorophosphate

Downstream raw materials:

N^α-(tert-butoxycarbonyl)-O-(O',O''-dimethylphosphoro)-L-tyrosine