N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester
• CAS No.: 923293-28-1
• Molecular Formula: C₂₄H₃₄N₂O₅
• Molecular Weight: 430.544

Synonyms:N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester

Chemical Property of N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester

There total 2 articles about N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-propargyl-L-norleucine methyl ester (923293-24-7) + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester (923293-28-1)

Guidance literature:

With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo0619635

Reference yield:

L-2-aminohexanoic acid-methyl ester hydrochloride (3844-54-0) → N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester (923293-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / triethylamine / CH₂Cl₂ / 40 °C

2: 87 percent / NMM; EDC / CH₂Cl₂ / 0 - 20 °C

With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane;

DOI:10.1021/jo0619635

Reference yield: 89.0%

N-tert-butoxycarbonyl-L-phenylalanyl-N-propargyl-L-norleucine methyl ester (923293-28-1) → L-phenylalanyl-N-propargyl-L-norleucine methyl ester hydrochloride

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jo0619635

upstream raw materials:

N-propargyl-L-norleucine methyl ester

N-tert-butoxycarbonyl-L-phenylalanine

L-2-aminohexanoic acid-methyl ester hydrochloride

Downstream raw materials:

cyclo-(L-phenylalanyl-N-propargyl-L-norleucinyl)

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