3844-54-0

Basic information

• Product Name: H-NLE-OME HCL
• Synonyms: NORLEUCINE-OME HCL;L-NORLEUCINE METHYL ESTER HYDROCHLORIDE;L-2-AMINOHEXANOIC ACID-METHYL ESTER HCL;L-2-AMINOHEXANOIC ACID METHYL ESTER HYDROCHLORIDE;H-NLE-OME HCL;H-Nle-Ome hydrochloride;(S)-methyl 2-aminohexanoate hydrochloride;(S)-2-Aminohexanoic acid methyl ester hydrochloride
• CAS NO: 3844-54-0
• Molecular Formula: C₇H₁₅NO₂*ClH
• Molecular Weight: 181.66
• Mol File: 3844-54-0.mol
• Article Data: 13

Chemical Properties

• Melting Point: 131-132℃
• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: H-NLE-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-NLE-OME HCL(3844-54-0)
• EPA Substance Registry System: H-NLE-OME HCL(3844-54-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 3844-54-0(Hazardous Substances Data)

Usage

General Description

H-NLE-OME HCL, also known as N-ethyleoleamid, is a synthetic chemical compound that belongs to the N-alkoylamino acid series. It is commonly used as a research chemical and has shown potential in various pharmacological and biological studies. H-NLE-OME HCL has been studied for its potential analgesic and anti-inflammatory properties, and it has also been investigated for its role in modulating neurotransmitter activity. Additionally, H-NLE-OME HCL has been considered as a potential precursor for the synthesis of new pharmaceutical compounds. However, its exact mechanism of action and potential uses in clinical applications are still under investigation, making it an area of interest for further research.

Upstream product

• 67-56-1 methanol 
• 616-06-8 2-amino-hexanoic acid 
• 203855-78-1 methyl 2-((diphenylmethylene)amino)hexanoate 
• 327-57-1 L-Norleucine 
• 687-64-9 L-lysine methyl ester 
• 127644-00-2 2-amino-(S,Z)-3-hexenoic acid hydrobromide 
• 127605-42-9 t-butyl 2-benzyloxycarbonylamino-(S,Z)-3-hexenoate 
• 123975-57-5 t-butyl 2-benzyloxycarbonylamino-3-allyloxycarbonyl-4-hydroxy-(2S)-hexanoate 
• 123975-61-1 t-butyl 2-benzyloxycarbonylamino-3-carboxy-4-hydroxy-(2S)-hexanoate 
• 1279107-64-0 methyl 2-benzylideneaminohexanoate 

Downstream Products

• 203855-78-1 methyl 2-((diphenylmethylene)amino)hexanoate 
• 1115355-18-4 (S)-2-(2-amino-5-methoxy-benzoylamino)-hexanoic acid methyl ester 
• 1115355-12-8 (S)-2-(2-amino-4-methoxy-benzoylamino)-hexanoic acid methyl ester 
• 5665-74-7 2-amino-1-hexanol 

Relevant articles and documents

Direct Deamination of Primary Amines via Isodiazene Intermediates

We report here a reaction that selectively deaminates primary amines and anilines under mild conditions and with remarkable functional group tolerance including a range of pharmaceutical compounds, amino acids, amino sugars, and natural products. An anomeric amide reagent is uniquely capable of facilitating the reaction through the intermediacy of an unprecedented monosubstituted isodiazene intermediate. In addition to dramatically simplifying deamination compared to existing protocols, our approach enables strategic applications of iminium and amine-directed chemistries as traceless methods. Mechanistic and computational studies support the intermedicacy of a primary isodiazene which exhibits an unexpected divergence from previously studied secondary isodiazenes, leading to cage-escaping, free radical species that engage in a chain, hydrogen-atom transfer process involving aliphatic and diazenyl radical intermediates.

Synthesis and bioactivity of novel 3-(1-hydroxyethylidene)-5-substituted- pyrrolidine-2,4-dione derivatives

Ten novel 5-substituted derivatives of 3-(1-hydroxyethylidene)pyrrolidine- 2,4-dione were synthesized. The compounds were confirmed by IR, 1H NMR, MS and elemental analysis. The bioassay indicated that these compounds showed noticeable herbicid

Tandem multi-step synthesis of C-carboxyazlactones promoted by N-heterocyclic carbenes

Cascade reaction sequences incorporating N-heterocyclic carbene-based organocatalysis have been developed that allow the direct preparation of a range of (±)-4-phenoxycarbonylazlactones in good isolated yields (66-84%) from the corresponding N-p-anisoyl amino acids. The Royal Society of Chemistry.