2-oxo-3-phenylpropyl cyanoacetate

Base Information

• Chemical Name: 2-oxo-3-phenylpropyl cyanoacetate
• CAS No.: 1238329-90-2
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.224
• Mol file: 1238329-90-2.mol

Synonyms:2-oxo-3-phenylpropyl cyanoacetate

Chemical Property of 2-oxo-3-phenylpropyl cyanoacetate

Chemical Property:

Purity/Quality:

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Technology Process of 2-oxo-3-phenylpropyl cyanoacetate

There total 1 articles about 2-oxo-3-phenylpropyl cyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-hydroxy-3-phenylpropan-2-one (4982-08-5) + cyanoacetic acid (372-09-8) → 2-oxo-3-phenylpropyl cyanoacetate (1238329-90-2)

Guidance literature:

With pyridine; N,N-dimethylphosphoroamidic dichloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201000318

Reference yield: 92.0%

2-oxo-3-phenylpropyl cyanoacetate (1238329-90-2) → 4-benzyl-2-oxotetrahydrofuran-3-carbonitrile (1238329-92-4)

Guidance literature:

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; L-proline; In ethanol; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201000318

upstream raw materials:

1-hydroxy-3-phenylpropan-2-one

cyanoacetic acid

Downstream raw materials:

4-benzyl-2-oxotetrahydrofuran-3-carbonitrile

Refernces