(R)-2-amino-3-hydroxy-2-benzylpropionic acid

Base Information

• Chemical Name: (R)-2-amino-3-hydroxy-2-benzylpropionic acid
• CAS No.: 185396-37-6
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.218
• Mol file: 185396-37-6.mol

Synonyms:(R)-2-amino-3-hydroxy-2-benzylpropionic acid

Chemical Property of (R)-2-amino-3-hydroxy-2-benzylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-amino-3-hydroxy-2-benzylpropionic acid

There total 19 articles about (R)-2-amino-3-hydroxy-2-benzylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester (851511-44-9) → (R)-2-amino-3-hydroxy-2-benzylpropionic acid (185396-37-6,4740-47-0)

Guidance literature:

With hydrogenchloride; for 20h; Heating;

DOI:10.1021/ol050228x

Reference yield: 92.0%

tert-butyl (R)-2-acetamido-2-benzyl-3-hydroxypropanoate → (R)-2-amino-3-hydroxy-2-benzylpropionic acid (185396-37-6,4740-47-0)

Guidance literature:

With hydrogenchloride; In methanol; water; for 48h; Reflux;

DOI:10.1021/jo502791d

Reference yield: 84.0%

(R)-4-benzyl-2-oxo-4-oxazolidinecarboxylic acid → (R)-2-amino-3-hydroxy-2-benzylpropionic acid (185396-37-6,4740-47-0)

Guidance literature:

(R)-4-benzyl-2-oxo-4-oxazolidinecarboxylic acid; With hydrogenchloride; water; for 12h; Reflux;

With ammonia; In water;

DOI:10.1016/j.tet.2012.06.090

upstream raw materials:

(R)-2-benzoylamino-2-benzyl-3-hydroxypropanoic acid

(S)-3-Benzyl-5-isopropyl-6-oxo-3,6-dihydro-2H-[1,4]oxazine-3-carbonitrile

(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

1-hydroxy-3-phenylpropan-2-one

Downstream raw materials:

(R)-2-tert-Butoxycarbonylamino-2-hydroxymethyl-3-phenyl-propionic acid

4-benzyl-3-[2-(tert-butyl-dimethyl-silanyloxy)-3-phenylsulfanyl-propionyl]-2-oxo-oxazolidine-4-carboxylic acid benzyl ester

8a-benzyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione

8a-benzyl-6-methylene-dihydro-oxazolo[4,3-c][1,4]oxazine-3,5,8-trione