(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester
CAS No.:851511-44-9
Molecular Formula:C₂₇H₂₇NO₃
Molecular Weight:413.516
Hs Code.:

Synonyms:(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

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Chemical Property of (R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

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Technology Process of (R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

There total 5 articles about (R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 851511-35-8
2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

: 100-39-0
benzyl bromide

: 851511-44-9
(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

Guidance literature:: With cesium hydroxide; dihydrocinchonidinium bromide-derived catalyst; In dichloromethane; at -40 ℃; for 8h;
DOI:10.1021/ol050228x

Reference yield:

: 2-(biphenyl-2-yl)-4,5-dihydrooxazole-4-carboxylic acid tert-butyl ester

: 100-39-0
benzyl bromide

: 851511-44-9
(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

: C₂₇H₂₇NO₃

Guidance literature:: With C₄₅H₅₄N₆O₉; sodium hydroxide; In water; toluene; at 0 ℃; for 96h; Overall yield = 44 %; enantioselective reaction;
DOI:10.1055/s-0036-1588102

Reference yield:

: 2-[(biphenyl-2-carbonyl)-amino]-3-hydroxy-propionic acid tert-butyl ester

: 851511-44-9
(R)-4-benzyl-2-biphenyl-2-yl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / DAST / CH₂Cl₂ / 2 h / -78 °C

2: 90 percent / dihydrocinchonidinium bromide-derived catalyst; CsOH / CH₂Cl₂ / 8 h / -40 °C

With cesium hydroxide; dihydrocinchonidinium bromide-derived catalyst; 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane;
DOI:10.1021/ol050228x