2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

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Chemical Name:2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole
CAS No.:1620515-36-7
Molecular Formula:C₁₈H₁₉ClN₆S
Molecular Weight:386.908
Hs Code.:

Synonyms:2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

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Chemical Property of 2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

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Technology Process of 2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

There total 4 articles about 2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 288-32-4
1H-imidazole

: 1620516-00-8
2-(2-chloro-4-iodophenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

: 1620515-36-7
2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

Guidance literature:: With copper(l) iodide; 2-(2'-pyridyl)benzimidazole; caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 145343-76-6
2-chloro-4-iodobenzoic acid

: 1620515-36-7
2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 22 h / 20 - 78 °C / Inert atmosphere; Cooling with ice; Sonication

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C / Inert atmosphere

3: 1-methyl-pyrrolidin-2-one / 19 h / 120 °C

4: 2-(2'-pyridyl)benzimidazole; caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

With copper(l) iodide; tert.-butylnitrite; 2-(2'-pyridyl)benzimidazole; caesium carbonate; copper(ll) bromide; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1388028-93-0
5-(2-chloro-4-iodophenyl)-1,3,4-thiadiazol-2-amine

: 1620515-36-7
2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 18 h / 20 °C / Inert atmosphere

2: 1-methyl-pyrrolidin-2-one / 19 h / 120 °C

3: 2-(2'-pyridyl)benzimidazole; caesium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 18 h / 90 °C / Inert atmosphere

With copper(l) iodide; tert.-butylnitrite; 2-(2'-pyridyl)benzimidazole; caesium carbonate; copper(ll) bromide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;