145343-76-6

Basic information

• Product Name: 2-CHLORO-4-IODOBENZOIC ACID
• Synonyms: 2-Chloro-4-iodobenzoic acid 96%
• CAS NO: 145343-76-6
• Molecular Formula: C₇H₄ClIO₂
• Molecular Weight: 282.46293
• Product Categories: Acids & Esters;Chlorine Compounds;Iodine Compounds;C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 145343-76-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 166-170 °C
• Boiling Point: 337.9 °C at 760 mmHg
• Flash Point: 158.2 °C
• Appearance: /
• Density: 2.077 g/cm³
• Vapor Pressure: 3.96E-05mmHg at 25°C
• Refractive Index: 1.673
• Storage Temp.: 2-8°C(protect from light)
• Solubility: soluble in Methanol
• PKA: 2.75±0.25(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-IODOBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-IODOBENZOIC ACID(145343-76-6)
• EPA Substance Registry System: 2-CHLORO-4-IODOBENZOIC ACID(145343-76-6)

Safety Data

• Hazard Codes: T,N
• Statements: 25-37/38-41-50/53
• Safety Statements: 26-36/37-45-60-61
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 145343-76-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-iodobenzoic acid is a chemical compound with the molecular formula C7H4ClIO2. It is a white to yellow solid that is sparingly soluble in water. It is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of dyes, pigments, and other organic compounds. Due to its reactivity and versatile nature, 2-chloro-4-iodobenzoic acid is a valuable chemical in the fields of medicinal chemistry and organic synthesis. 2-CHLORO-4-IODOBENZOIC ACID is also known by its CAS number 6209-52-1.

InChI:InChI=1/C7H4ClIO2/c8-6-3-4(9)1-2-5(6)7(10)11/h1-3H,(H,10,11)

Upstream product

• 2457-76-3 4-amino-2-chlorobenzoic acid 
• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 

Downstream Products

• 860732-53-2 2-p-anisidino-4-iodo-benzoic acid 
• 104-94-9 4-methoxy-aniline 
• 158580-98-4 4-iodo-2-(N-methyl-N-methylsulphonyl)aminobenzoic acid 
• 156573-32-9 methyl 2-chloro-4-iodobenzoate 
• 1426833-15-9 1-(2-chloro-4-iodo-phenyl)-4-methyl-2,3,5,9,9b-pentaazacyclopenta[a]naphthalene 
• 610-96-8 methyl chlorobenzoate 
• 1206599-46-3 2-chloro-4-iodo-1-(trifluoromethyl)benzene 
• 56363-84-9 2-chloro-4-hydroxybenzoic acid 
• 92712-69-1 ethyl 2-chloro-4-iodobenzoate 
• 1620515-36-7 2-(2-chloro-4-(1H-imidazol-1-yl)phenyl)-5-((3aR,6aS)-5-methylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,3,4-thiadiazole 

Relevant articles and documents

Method for preparing iodo-benzoic acid (ester) by improving moral Michael reaction

The invention discloses a method for preparing iodo-benzoic acid (ester) by improving a moral reaction, and belongs to the technical field of organic synthesis. The method comprises the following steps: preparing and separating the diazonium tetrafluoroborate through diazotization of aminobenzoic acid (ester) and then performing iodination reaction with the iodinated reagent in an organic medium to obtain the corresponding iodo carboxylic acid (ester). The iodo-benzoic acid (ester) prepared by the method has high purity. The method has the advantages of good quality and simple post-treatment, and the product yield reaches 70 - 90%.

TRICYCLIC VASOPRESSIN AGONISTS

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RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof

Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): wherein Ar is a radical having one of the formulae (a)-(e): which are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders are provided. In particular, based on their RXR-agonist activity, these compounds may be used to treat noninsulin-dependent diabetes mellitus (NIDDM) and obesity.