N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

Base Information

Chemical Name:N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine
CAS No.:1383715-90-9
Molecular Formula:C₁₉H₂₆N₆
Molecular Weight:338.456
Hs Code.:

N<sub>2</sub>-cyclohexyl-4'-cyclopropylmethyl-N<sub>2</sub>'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

Synonyms:N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

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Chemical Property of N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

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Technology Process of N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

There total 6 articles about N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.9%

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 1383716-79-7
4'-(cyclopropylmethyl)-N-methyl-2-(methylsulfinyl)-4,5'-bipyrimidin-2'-amine

: 1383715-90-9
N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

Guidance literature:: 6-methoxy-pyridin-3-ylamine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

4'-(cyclopropylmethyl)-N-methyl-2-(methylsulfinyl)-4,5'-bipyrimidin-2'-amine; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 1383715-90-9
N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; tert-butyl methyl ether / -10 - 20 °C / Inert atmosphere

1.2: -10 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 2 h / 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 - 120 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

5.1: dimethyl sulfoxide / 0.17 h / 160 °C / Microwave irradiation

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.5b00335

Reference yield:

: 227322-00-1
2-cyclopropyl-N-methoxy-N-methyl-acetamide

: 1383715-90-9
N₂-cyclohexyl-4'-cyclopropylmethyl-N₂'-methyl-[4,5']bipyrimidinyl-2,2'-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; tert-butyl methyl ether / -10 - 20 °C / Inert atmosphere

1.2: -10 - 20 °C / Inert atmosphere

2.1: N,N-dimethyl acetamide / 2 h / 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 - 120 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

5.1: dimethyl sulfoxide / 0.17 h / 160 °C / Microwave irradiation

With potassium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.5b00335