(S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:382141-40-4
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:(S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

Suppliers and Price of (S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

There total 7 articles about (S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32159-21-0
Cbz-L-pGlu-OH

: 382141-40-4
(S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / -10 °C

1.2: 61 percent / NaBH₄ / methanol / 0 °C

2.1: 92 percent / DIBAL-H / CH₂Cl₂ / -78 °C

3.1: 93 percent / p-TsOH / 20 °C

4.1: 90 percent / pyridine / 0 °C

5.1: 60 percent / NaI; CaCO₃ / dimethylformamide / 80 °C

6.1: SO₃-pyridine; Et₃N / dimethylsulfoxide / 20 °C

7.1: tetrahydrofuran / 20 °C

With 4-methyl-morpholine; pyridine; pyridine-SO₃ complex; chloroformic acid ethyl ester; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; calcium carbonate; sodium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 7.1: Wittig reaction;
DOI:10.1016/S0040-4039(01)01583-0

Reference yield:

: 153870-19-0
benzyl (2S)-2-(hydroxymethyl)-5-oxopyrrolidine-1-carboxylate

: 382141-40-4
(S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / DIBAL-H / CH₂Cl₂ / -78 °C

2: 93 percent / p-TsOH / 20 °C

3: 90 percent / pyridine / 0 °C

4: 60 percent / NaI; CaCO₃ / dimethylformamide / 80 °C

5: SO₃-pyridine; Et₃N / dimethylsulfoxide / 20 °C

6: tetrahydrofuran / 20 °C

With pyridine; pyridine-SO₃ complex; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; calcium carbonate; sodium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 6: Wittig reaction;
DOI:10.1016/S0040-4039(01)01583-0

Reference yield:

: 382141-34-6
(S)-2-Hydroxy-5-hydroxymethyl-pyrrolidine-1-carboxylic acid benzyl ester

: 382141-40-4
(S)-2-Methoxy-5-((E)-2-methoxycarbonyl-vinyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / p-TsOH / 20 °C

2: 90 percent / pyridine / 0 °C

3: 60 percent / NaI; CaCO₃ / dimethylformamide / 80 °C

4: SO₃-pyridine; Et₃N / dimethylsulfoxide / 20 °C

5: tetrahydrofuran / 20 °C

With pyridine; pyridine-SO₃ complex; toluene-4-sulfonic acid; triethylamine; calcium carbonate; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; 5: Wittig reaction;
DOI:10.1016/S0040-4039(01)01583-0