(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate)

Base Information

• Chemical Name: (ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate)
• CAS No.: 1176870-30-6
• Molecular Formula: C₂₂H₂₇NO₃S
• Molecular Weight: 385.527
• Mol file: 1176870-30-6.mol

Synonyms:(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate)

Chemical Property of (ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate)

There total 1 articles about (ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

1-(3,5-dimethylphenyl)-4-hydroxybutan-1-one (452308-54-2) + tert-butyl 1-[5-(2-ethoxy-1,1-dimethyl-2-oxoethyl)-3-thienyl]hydrazine carboxylate hydrochloride (1176870-28-2) → (ethyl 2-[5-(3,5-dimethylphenyl)-6-(2-hydroxyethyl)-4H-thieno[3,2-b]pyrrol-2-yl]-2-methylpropanoate) (1176870-29-3) + (ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate) (1176870-30-6)

Guidance literature:

With zinc(II) chloride; In iso-butanol; at 20 - 110 ℃; for 5h;

DOI:10.1016/j.tet.2009.05.007

Reference yield: 78.0%

(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate) (1176870-30-6) → 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid (1176870-34-0)

Guidance literature:

(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate); With water; sodium hydroxide; In ethanol; at 70 ℃; for 3h;

With hydrogenchloride; In water; at 5 ℃; pH=1;

DOI:10.1016/j.tet.2009.05.007

upstream raw materials:

1-(3,5-dimethylphenyl)-4-hydroxybutan-1-one

tert-butyl 1-[5-(2-ethoxy-1,1-dimethyl-2-oxoethyl)-3-thienyl]hydrazine carboxylate hydrochloride

Downstream raw materials:

2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid