2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid

Base Information

• Chemical Name: 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid
• CAS No.: 1176870-34-0
• Molecular Formula: C₂₀H₂₃NO₃S
• Molecular Weight: 357.474
• Mol file: 1176870-34-0.mol

Synonyms:2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid

Chemical Property of 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid

There total 1 articles about 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate) (1176870-30-6) → 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid (1176870-34-0)

Guidance literature:

(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate); With water; sodium hydroxide; In ethanol; at 70 ℃; for 3h;

With hydrogenchloride; In water; at 5 ℃; pH=1;

DOI:10.1016/j.tet.2009.05.007

Reference yield: 49.0%

2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoic acid (1176870-34-0) + 7-azabicyclo[2.2.1]heptane hydrochloride (27514-07-4) → 2-[4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-thieno[3,4-b]pyrrol-3-yl]ethanol (1176870-35-1)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 1.08333h;

DOI:10.1016/j.tet.2009.05.007

upstream raw materials:

(ethyl 2-[2-(3,5-dimethylphenyl)-3-(2-hydroxyethyl)-1H-thieno[3,4-b]pyrrol-4-yl]-2-methylpropanoate)

Downstream raw materials:

2-[4-[2-(7-azabicyclo[2.2.1]hept-7-yl)-1,1-dimethyl-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-thieno[3,4-b]pyrrol-3-yl]ethanol