(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

Base Information

Chemical Name:(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane
CAS No.:1338719-39-3
Molecular Formula:C₂₇H₃₉NO₂SSi
Molecular Weight:469.764
Hs Code.:

Synonyms:(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

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Chemical Property of (1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

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Technology Process of (1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

There total 2 articles about (1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1338719-42-8
(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[((S)-tert-butylsulfinyl)iminomethyl]cyclopropane

: 1826-67-1
vinyl magnesium bromide

: 1338719-39-3
(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

Guidance literature:: (1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[((S)-tert-butylsulfinyl)iminomethyl]cyclopropane; vinyl magnesium bromide; In tetrahydrofuran; toluene; at 110 ℃; Inert atmosphere;

With methanol; In tetrahydrofuran; toluene; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.bmc.2011.08.049

Reference yield:

: 408348-31-2
(1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

: 1338719-39-3
(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(II) sulfate / dichloromethane / 20 °C / Inert atmosphere

2.1: tetrahydrofuran; toluene / 110 °C / Inert atmosphere

2.2: Inert atmosphere

With copper(II) sulfate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmc.2011.08.049

Reference yield:

: 1338719-39-3
(1R,2R)-2-((tert-butyldiphenylsiloxy)methyl)-1-[(1R)-1-((S)-tert-butylsulfinylamino)-2-propenyl]cyclopropane

: C₃₂H₃₄N₄O₆

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / methanol; ethyl acetate / 1.5 h / 20 °C / Inert atmosphere

2: sodium carbonate / tetrahydrofuran; water; toluene / 12 h / 20 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 2 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; water; ethyl acetate; toluene; 3: Mitsunobu reaction;
DOI:10.1016/j.bmc.2011.08.049