methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate
CAS No.:1408186-50-4
Molecular Formula:C₁₂H₁₂Cl₂N₄O₄S
Molecular Weight:379.224
Hs Code.:

Synonyms:methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

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Chemical Property of methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

Chemical Property:

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Technology Process of methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

There total 3 articles about methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₅Cl₂NO₇S₂

: 1408186-50-4
methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 1408186-50-4
methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 90 °C

With dmap; thionyl chloride; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-50-4
methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 90 °C

With dmap; sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.08.028