methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate
CAS No.:1408186-54-8
Molecular Formula:C₂₀H₁₈Cl₂N₄O₄S
Molecular Weight:481.359
Hs Code.:

Synonyms:methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

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Chemical Property of methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

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Technology Process of methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

There total 3 articles about methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1408186-50-4
methyl (2R,4S)-4-azido-1-(3,4-dichlorophenylsulfonyl)pyrrolidine-2-carboxylate

: 536-74-3
phenylacetylene

: 1408186-54-8
methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

Guidance literature:: With copper diacetate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: 114676-47-0,775275-31-5,790644-51-8,754962-86-2
(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester

: 1408186-54-8
methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 90 °C

4: sodium L-ascorbate; copper diacetate / water; tert-butyl alcohol / 20 °C

With dmap; sodium azide; copper diacetate; sodium L-ascorbate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2012.08.028

Reference yield:

: C₁₃H₁₅Cl₂NO₇S₂

: 1408186-54-8
methyl (2R,4S)-1-(3,4-dichlorophenylsulfonyl)-4-(4-phenyl-1H-1,2,3-triazol-1-yl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 90 °C

2: sodium L-ascorbate; copper diacetate / water; tert-butyl alcohol / 20 °C

With sodium azide; copper diacetate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2012.08.028