Technology Process of 2-(4-Acetylamino-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide
There total 6 articles about 2-(4-Acetylamino-phenyl)-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: H2, aq. NaOH / Pd/C
2: cupric acetate, AcOH / H2O; methanol / Heating
3: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min
With
sodium hydroxide; hydrogen; copper diacetate; acetic acid; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
methanol; water;
DOI:10.1021/jm00164a054
- Guidance literature:
-
Multi-step reaction with 4 steps
1: aq. KOH / Heating
2: H2, aq. NaOH / Pd/C
3: cupric acetate, AcOH / H2O; methanol / Heating
4: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min
With
potassium hydroxide; sodium hydroxide; hydrogen; copper diacetate; acetic acid; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
methanol; water;
DOI:10.1021/jm00164a054
- Guidance literature:
-
Multi-step reaction with 7 steps
1: SOCl2 / 1 h / Heating
2: aq. NaN3 / acetone / 1 h / below 25 deg C
3: aq. AcOH / 0.17 h / Heating
4: aq. KOH / Heating
5: H2, aq. NaOH / Pd/C
6: cupric acetate, AcOH / H2O; methanol / Heating
7: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min
With
potassium hydroxide; sodium hydroxide; thionyl chloride; sodium azide; hydrogen; copper diacetate; acetic acid; 1,1'-carbonyldiimidazole;
palladium on activated charcoal;
In
methanol; water; acetone;
DOI:10.1021/jm00164a054
