3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

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Chemical Name:3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester
CAS No.:646532-04-9
Molecular Formula:C₃₅H₄₆N₄O₉
Molecular Weight:666.772
Hs Code.:

3-(<i>N</i>-<i>tert</i>-butoxycarbonylmethyl-<i>N</i>'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

Synonyms:3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

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Chemical Property of 3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

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Technology Process of 3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

There total 5 articles about 3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 646532-77-6
3-phenylpropanoyl-Val-Ala-NHNHCH₂COO-t-Bu

: 646532-94-7
(2S,3S)-oxirane-2,3-dicarboxylic acid monophenethyl ester

: 646532-04-9
3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm0305016

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 646532-04-9
3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / 4-methylmorpholine / dimethylformamide / 20.5 h / -10 - 20 °C

2: 61 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm0305016

Reference yield:

: 60-12-8
2-phenylethanol

: 646532-04-9
3-(N-tert-butoxycarbonylmethyl-N'-{2-[3-methyl-2-(3-phenyl-propionylamino)-butyrylamino]-propionyl}-hydrazinocarbonyl)-oxirane-2-carboxylic acid phenethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine / dimethylformamide / 15 h / 20 °C

2: 61 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 16 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;
DOI:10.1021/jm0305016