2-N-CBZ-AMINO-CYCLOHEXANONE

Base Information

• Chemical Name: 2-N-CBZ-AMINO-CYCLOHEXANONE
• CAS No.: 31236-61-0
• Molecular Formula: C14H17 N O3
• Molecular Weight: 247.294
• Hs Code.: 2924299090
• Mol file: 31236-61-0.mol

Synonyms:Carbamicacid, (2-oxocyclohexyl)-, phenylmethyl ester (9CI); Cyclohexanecarbamic acid,2-oxo-, benzyl ester (8CI)

Chemical Property of 2-N-CBZ-AMINO-CYCLOHEXANONE

Chemical Property:

• Boiling Point: 427.3±44.0 °C(Predicted)
• PKA: 10.98±0.20(Predicted)
• PSA: 55.40000
• Density: 1.17±0.1 g/cm3(Predicted)
• LogP: 2.81540

Purity/Quality:

99% ^*data from raw suppliers

Benzyl(2-oxocyclohexyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Statements: 52

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-N-CBZ-AMINO-CYCLOHEXANONE

There total 8 articles about 2-N-CBZ-AMINO-CYCLOHEXANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclohexanol (92645-06-2) → (+/-)-2-cyclohexanone (31236-61-0)

Guidance literature:

With oxalyl dichloride; triethylamine; In dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)95241-9

Reference yield:

2-aminocyclohexanol (6850-38-0) → (+/-)-2-cyclohexanone (31236-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / methanol

2: (ClCO)2, Et₃N / dimethylsulfoxide

With oxalyl dichloride; sodium hydrogencarbonate; triethylamine; In methanol; dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)95241-9

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → (+/-)-2-cyclohexanone (31236-61-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₄OH / methanol / Heating

2: aq. NaHCO₃ / methanol

3: (ClCO)2, Et₃N / dimethylsulfoxide

With ammonium hydroxide; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; In methanol; dimethyl sulfoxide;

DOI:10.1016/S0040-4039(00)95241-9

upstream raw materials:

1-methoxy-cyclohex-1-ene

benzyl N-chlorocarbamate

(2,2-Dimethoxy-cyclohexyl)-carbamic acid benzyl ester

2-cyclohexanol

Downstream raw materials:

N-(2-oxocyclohexyl)acetamide

(1R*,2S*)-(+/-)--1-ethenyl-1-cyclohexanol

(1S*,2S*)-(+/-)-2--1-ethenyl-1-cyclohexanol

(3aS,7aR)-7a-Vinyl-hexahydro-benzooxazol-2-one