bis[4-(trifluoromethyl)phenyl]zinc

Base Information

• Chemical Name: bis[4-(trifluoromethyl)phenyl]zinc
• CAS No.: 858344-44-2
• Molecular Formula: C₁₄H₈F₆Zn
• Molecular Weight: 355.598
• Mol file: 858344-44-2.mol

Synonyms:bis[4-(trifluoromethyl)phenyl]zinc

Chemical Property of bis[4-(trifluoromethyl)phenyl]zinc

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis[4-(trifluoromethyl)phenyl]zinc

There total 7 articles about bis[4-(trifluoromethyl)phenyl]zinc which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

p-trifluoromethylphenyl bromide (402-43-7) + zinc(II) chloride (7646-85-7,24359-56-6) → bis[4-(trifluoromethyl)phenyl]zinc (858344-44-2)

Guidance literature:

With n-butyllithium; In diethyl ether; byproducts: LiBr; under N2; soln. of p-CF3C6H4Br in Et2O added to soln. of n-BuLi in Et2O at -78°C, mixt. stirred at -78°C for 1 h, soln. of ZnCl2 in Et2O added, soln. slowly warmed to room temp., stirred overnight; LiBr removed by filtration, filtrate evapd. under vac., sublimation at 110°C/1E-2 mbar; elem. anal.;

DOI:10.1021/ic048332i

Reference yield: 40.0%

4-Iodobenzotrifluoride (455-13-0) + zinc(II) chloride (7646-85-7,24359-56-6) → bis[4-(trifluoromethyl)phenyl]zinc (858344-44-2)

Guidance literature:

4-Iodobenzotrifluoride; With n-butyllithium; at -78 ℃; Inert atmosphere;

zinc(II) chloride; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1039/d1cc04137a

Reference yield:

p-trifluoromethylphenyl bromide (402-43-7) + zinc dibromide (7699-45-8) → bis[4-(trifluoromethyl)phenyl]zinc (858344-44-2)

Guidance literature:

p-trifluoromethylphenyl bromide; With magnesium; In tetrahydrofuran; at 80 ℃; for 0.666667h; Inert atmosphere; Sealed tube;

zinc dibromide; With lithium chloride; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jacs.7b11976

upstream raw materials:

p-trifluoromethylphenyl bromide

zinc(II) chloride

4-Iodobenzotrifluoride

zinc dibromide

Downstream raw materials:

(p-CF3C6H4)2Zn2(μ-OCHPr(i)2)2

(2R,3R,4R,5S,6S)-2-(pivaloyloxymethyl)-6-(4-(trifluoromethyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyltris(2,2-dimethylpropanoate)

2-(4-(trifluoro-methyl)phenyl)naphthalene

1-(difluoromethyl)-4-(trifluoromethyl)benzene