C₄₉H₄₁N₃O₅SSi

Base Information

• Chemical Name: C₄₉H₄₁N₃O₅SSi
• CAS No.: 144127-83-3
• Molecular Formula: C₄₉H₄₁N₃O₅SSi
• Molecular Weight: 812.033
• Mol file: 144127-83-3.mol

Synonyms:C₄₉H₄₁N₃O₅SSi

Chemical Property of C₄₉H₄₁N₃O₅SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₉H₄₁N₃O₅SSi

There total 14 articles about C₄₉H₄₁N₃O₅SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C45H39NO5Si (144127-82-2) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → C49H41N3O5SSi (144127-83-3)

Guidance literature:

With dmap; In dichloromethane; at 25 ℃; for 60h;

DOI:10.1021/ja00049a022

Reference yield:

2-hydroxy-7,8,9,10-tetrahydrophenanthridine (100713-03-9) → C49H41N3O5SSi (144127-83-3)

Guidance literature:

Multi-step reaction with 13 steps

1: 100 percent / pyridine / 24 h / 0 °C

2: 97 percent / diethylamine, copper(I) iodide, bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 11 h

3: 91 percent / m-CPBA / CH₂Cl₂ / 1 h / 25 °C

4: 91 percent / 1 h / 70 °C

5: 69 percent / Dowex 1*8-200 / methanol / 24 h / 60 °C

6: 88 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

7: 1.) THF, from -78 deg C to 0 deg C, 2.) THF, from -78 deg C to 0 deg C, 2 h

8: 87 percent / m-CPBA, buffer solution (pH 7.5) / CH₂Cl₂ / 2 h / 25 °C

9: 92 percent / HF, Pyr / tetrahydrofuran / 24 h / 25 °C

10: 90 percent / pyridinium chlorochromate (PCC), molecular sieves 4A / CH₂Cl₂ / 3 h / 25 °C

11: 67 percent / copper(I) iodide, n-butylamine, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 3.5 h / 25 °C

12: 90 percent / LDA / toluene / 0.5 h / -78 °C

13: 76 percent / DMAP / CH₂Cl₂ / 60 h / 25 °C

With pyridine; 2,6-dimethylpyridine; dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(triphenylphosphine)palladium(II)-chloride; 4 A molecular sieve; buffer solution; Dowex 1*8-200; hydrogen fluoride; diethylamine; N-butylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja00049a022

Reference yield:

2-methoxy-7,8,9,10-tetrahydro-phenanthridine (35417-86-8) → C49H41N3O5SSi (144127-83-3)

Guidance literature:

Multi-step reaction with 14 steps

1: sodium ethanethiolate / dimethylformamide / 4 h / 160 °C

2: 100 percent / pyridine / 24 h / 0 °C

3: 97 percent / diethylamine, copper(I) iodide, bis(triphenylphosphine)palladium(II) chloride / dimethylformamide / 11 h

4: 91 percent / m-CPBA / CH₂Cl₂ / 1 h / 25 °C

5: 91 percent / 1 h / 70 °C

6: 69 percent / Dowex 1*8-200 / methanol / 24 h / 60 °C

7: 88 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

8: 1.) THF, from -78 deg C to 0 deg C, 2.) THF, from -78 deg C to 0 deg C, 2 h

9: 87 percent / m-CPBA, buffer solution (pH 7.5) / CH₂Cl₂ / 2 h / 25 °C

10: 92 percent / HF, Pyr / tetrahydrofuran / 24 h / 25 °C

11: 90 percent / pyridinium chlorochromate (PCC), molecular sieves 4A / CH₂Cl₂ / 3 h / 25 °C

12: 67 percent / copper(I) iodide, n-butylamine, tetrakis(triphenylphosphine)palladium⁽⁰⁾ / tetrahydrofuran / 3.5 h / 25 °C

13: 90 percent / LDA / toluene / 0.5 h / -78 °C

14: 76 percent / DMAP / CH₂Cl₂ / 60 h / 25 °C

With pyridine; 2,6-dimethylpyridine; dmap; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(triphenylphosphine)palladium(II)-chloride; 4 A molecular sieve; buffer solution; Dowex 1*8-200; hydrogen fluoride; diethylamine; N-butylamine; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; lithium diisopropyl amide; sodium thioethylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja00049a022

upstream raw materials:

C₄₅H₃₉NO₅Si

1,1'-Thiocarbonyldiimidazole

2-hydroxy-7,8,9,10-tetrahydrophenanthridine

2-methoxy-7,8,9,10-tetrahydro-phenanthridine

Downstream raw materials:

C₃₁H₂₅NO₄S

C₃₁H₂₅NO₆S

C₄₇H₄₃NO₄SSi

C₄₅H₃₉NO₄Si