2-Thiophenecarboxamide,N-(4-methoxyphenyl)-

Base Information

• Chemical Name: 2-Thiophenecarboxamide,N-(4-methoxyphenyl)-
• CAS No.: 39880-80-3
• Molecular Formula: C12H11 N O S
• Molecular Weight: 217.291
• Mol file: 39880-80-3.mol

Synonyms:2-Thiophenecarboxy-p-toluidide(7CI)

Chemical Property of 2-Thiophenecarboxamide,N-(4-methoxyphenyl)-

Chemical Property:

• PSA: 57.34000
• LogP: 3.38180

Purity/Quality:

99% ^*data from raw suppliers

N-(4-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenecarboxamide,N-(4-methoxyphenyl)-

There total 8 articles about 2-Thiophenecarboxamide,N-(4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

p-toluidine (106-49-0,12221-03-3) + (1H-benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone (301164-69-2) → N-(4-methylphenyl)thiophene-2-carboxamide (39880-80-3)

Guidance literature:

In chloroform; at 80 ℃; for 0.166667h; microwave irradiation;

DOI:10.1021/jo052443x

Reference yield: 58.0%

thiophene-2-carbaldehyde (98-03-3) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)thiophene-2-carboxamide (39880-80-3)

Guidance literature:

With potassium bromate; In water; at 80 ℃; Microwave irradiation;

DOI:10.1007/s10562-019-02878-5

Reference yield: 57.0%

2-thiopheneglyoxylic acid (4075-59-6) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)thiophene-2-carboxamide (39880-80-3)

Guidance literature:

With silver trifluoromethanesulfonate; In water; acetonitrile; at 60 ℃; for 24h; Schlenk technique;

DOI:10.1039/c6ob01963c

upstream raw materials:

2-Thiophenecarbonyl chloride

p-toluidine

2-thiophenecarbonyl azide

(1H-benzo[d][1,2,3]triazol-1-yl)(thiophen-2-yl)methanone

Downstream raw materials:

N-[(1H-1,2,3-benzotriazol-1-yl)(thien-2-yl)methylidene]-N-(4-methylphenyl)amine

N-(thiophen-2-yl(p-tolylimino)methyl)-N-p-tolylthiophene-2-carboxamide

C₂₂H₁₉NO₃S

C₂₂H₁₉NO₃S

Refernces

• 1、 Dandia, Anshu,Parihar, Sonam,Saini, Pratibha,Rathore, Kuldeep S.,Parewa, Vijay. "Metal-Free Sustainable Synthesis of Amides via Oxidative Amidation Using Graphene Oxide as Carbocatalyst in Aqueous Medium". . p. 3169 - 3175. Retrieved 2019/07/30.
• 2、 Xu, Wen-Tao,Huang, Bei,Dai, Jian-Jun,Xu, Jun,Xu, Hua-Jian. "Catalyst-Free Singlet Oxygen-Promoted Decarboxylative Amidation of α-Keto Acids with Free Amines". supporting information. p. 3114 - 3117. Retrieved 2016/07/14.