N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Base Information

• Chemical Name: N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester
• CAS No.: 102307-13-1
• Molecular Formula: C₄₀H₆₇N₁₅O₁₃
• Molecular Weight: 966.065
• Mol file: 102307-13-1.mol

Synonyms:N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Chemical Property of N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester

There total 9 articles about N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-N^G-nitroarginyl-N^G-nitroarginylisoleucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine (102307-08-4) + NG-nitroarginyl-NG-nitroarginylisoleucine methyl ester hydrochloride → 1,3-Dicyclohexylurea (2387-23-7) + N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-NG-nitroarginyl-NG-nitroarginylisoleucine methyl ester (102307-13-1)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h;

DOI:10.1021/jm00157a018

Reference yield:

t-butoxycarbonylhydrazine (870-46-2) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-NG-nitroarginyl-NG-nitroarginylisoleucine methyl ester (102307-13-1)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / CHCl₃ / 23 °C

2: 81 percent / N-hydroxybenzotriazole (HOBt) / dimethylformamide / 15 h / 23 °C

3: 92 percent / H₂ / 10percent Pd/C / methanol; dimethylformamide / 4 h / 760 Torr

4: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a018

Reference yield:

C12H13Cl3N2O4 (102307-06-2) → N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucyl-NG-nitroarginyl-NG-nitroarginylisoleucine methyl ester (102307-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / N-hydroxybenzotriazole (HOBt) / dimethylformamide / 15 h / 23 °C

2: 92 percent / H₂ / 10percent Pd/C / methanol; dimethylformamide / 4 h / 760 Torr

3: 1.) triethylamine (TEA), 2.) N-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / 1.) DMF, 23 deg C, 0.5 h, 2.) DMF a.) 0 deg C, 2 h, b.) 23 deg C, 15 h

With hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00157a018

upstream raw materials:

N-<2-(tert-butoxycarbonyl)hydrazino>carbonyl>phenylalanylleucine

t-butoxycarbonylhydrazine

Boc-Arg(NO₂)-OH

methyl L-isoleucinate hydrochloride

Downstream raw materials:

C₃₅H₆₁N₁₃O₇