2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

Base Information

Chemical Name:2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester
CAS No.:874452-38-7
Molecular Formula:C₂₂H₂₈N₄O₁₀
Molecular Weight:508.485
Hs Code.:

Synonyms:2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

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Chemical Property of 2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

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Technology Process of 2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

There total 8 articles about 2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₇N₃O₁₀

: 107-14-2
chloroacetonitrile

: 874452-38-7
2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 24h;
DOI:10.1002/chem.200500531

Reference yield:

: 2-(pent-4-enoyl)amino-4-hydroxybutanoic acid

: 874452-38-7
2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 2.3 g / benzyltriethylamine chloride; K₂CO₃ / dimethylformamide / 6 h / 55 °C

2.1: Et₃N / CH₂Cl₂ / 1 h / 0 °C

3.1: 86 mg / LiBr / acetone; CH₂Cl₂ / 19 h

4.1: NaH / dimethylformamide / 0.08 h

4.2: 69 percent / dimethylformamide / 1 h / 0 °C

5.1: TFA / 1 h

6.1: Et₃N / dioxane; H₂O / 2 h / 0 °C

7.1: 68 mg / Et₃N / acetonitrile / 24 h / 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; lithium bromide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1002/chem.200500531

Reference yield:

: 874452-36-5
2-(pent-4-enoyl)amino-4-bromobutanoic acid tert-butyl ester

: 874452-38-7
2-(pent-4-enoyl)amino-4-[O-[N-methyl-(N-6-nitroveratryloxycarbonyl)]amino]hydroxybutanoic acid cyanomethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.08 h

1.2: 69 percent / dimethylformamide / 1 h / 0 °C

2.1: TFA / 1 h

3.1: Et₃N / dioxane; H₂O / 2 h / 0 °C

4.1: 68 mg / Et₃N / acetonitrile / 24 h / 20 °C

With sodium hydride; triethylamine; trifluoroacetic acid; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.200500531