1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione

Base Information

• Chemical Name: 1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione
• CAS No.: 1182277-93-5
• Molecular Formula: C₂₅H₃₁NO₃Si
• Molecular Weight: 421.612
• Mol file: 1182277-93-5.mol

Synonyms:1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione

Chemical Property of 1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione

There total 1 articles about 1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-[(1R)-1-(hydroxymethyl)-2-propenyl]-2,6-piperidinedinone (1182277-91-3) + tert-butylchlorodiphenylsilane (58479-61-1) → 1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione (1182277-93-5)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/jo901059n

Reference yield: 93.0%

1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione (1182277-93-5) → 1-[(1R)-1-(1-tert-butyldiphenylsilyloxymethyl)-2-propenyl]-6-hydroxyhexahydro-2-pyridinone (1182277-94-6)

Guidance literature:

1-[(1R)-1-(tert-butyldiphenylsilyloxymethyl)-2-propenyl]-2,6-piperidinedione; With lithium triethylborohydride; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

With dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; at -78 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo901059n

upstream raw materials:

1-[(1R)-1-(hydroxymethyl)-2-propenyl]-2,6-piperidinedinone

tert-butylchlorodiphenylsilane

Downstream raw materials:

1-[(1R)-1-(1-tert-butyldiphenylsilyloxymethyl)-2-propenyl]-6-hydroxyhexahydro-2-pyridinone