methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

Base Information

Chemical Name:methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate
CAS No.:1427803-63-1
Molecular Formula:C₂₂H₃₂N₂O₉
Molecular Weight:468.504
Hs Code.:

Synonyms:methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

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Chemical Property of methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

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Technology Process of methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

There total 1 articles about methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1067639-93-3
3-{[(1,1-dimethylethoxy)carbonyl]aminooxy}-N-[(phenylmethoxy)carbonyl]-L-serine methyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 1427803-63-1
methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

: 1427803-64-2
methyl (S)-2-{[(benzyloxy)carbonyl](tert-butoxycarbonyl)amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

Guidance literature:: With dmap; In tetrahydrofuran; at 20 ℃; for 17h;
DOI:10.1055/s-0032-1317689

Reference yield:

: 1427803-63-1
methyl (S)-2-{[(benzyloxy)carbonyl]amino}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

: 1427803-66-4
methyl (S)-2-{2-[4-{[(benzyloxy)carbonyl]amino}-2-oxopyrimidin-1(2H)-yl]acetamido}-3-{[bis(tert-butoxycarbonyl)amino]oxy}propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 0.17 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 18 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1055/s-0032-1317689