2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

Base Information

Chemical Name:2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine
CAS No.:130449-62-6
Molecular Formula:C₂₆H₂₉N₆O₉P
Molecular Weight:600.525
Hs Code.:

Synonyms:2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

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Chemical Property of 2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

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Technology Process of 2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

There total 6 articles about 2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 24630-67-9
hydroxymethyl-phosphonic acid dimethyl ester

: 130449-61-5
2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<(vinyloxy)methyl>purine

: 130449-62-6
2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 23 ℃; for 2h;
DOI:10.1016/S0040-4039(00)89037-1

Reference yield:

: 112233-74-6
N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

: 130449-62-6
2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

Guidance literature:: Multi-step reaction with 3 steps

2: 1.) 30percent H₂O₂, sodium bicarbonate, 2.) diisopropylethylamine / 1.) dioxane, 60 deg C, 20 min, 2.) dioxane, 80 deg C, 30 min

3: 42 percent / m-chloroperbenzopic acid (MCPBA) / CH₂Cl₂ / 18 h / 25 °C

With dihydrogen peroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm00111a052

Reference yield:

: 130427-54-2
2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-phenylselenyl)ethoxy>methyl>purine

: 130449-62-6
2-(acetylamino)-6-<(diphenylcarbamoyl)oxy>-9-<<2-hydroxy-1-<(dimethoxyphosphinyl)methoxy>ethoxy>methyl>purine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 30percent H₂O₂, sodium bicarbonate, 2.) diisopropylethylamine / 1.) dioxane, 60 deg C, 20 min, 2.) dioxane, 80 deg C, 30 min

2: 42 percent / m-chloroperbenzopic acid (MCPBA) / CH₂Cl₂ / 18 h / 25 °C

With dihydrogen peroxide; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/jm00111a052