24630-67-9

Basic information

• Product Name: Dimethyl hydroxymethylphosphonate
• Synonyms: Dimethyl hydroxymethylphosphonate;Hydroxymethylphosphonic acid dimethyl ester
• CAS NO: 24630-67-9
• Molecular Formula: C₃H₉O₄P
• Molecular Weight: 140.07
• Mol File: 24630-67-9.mol
• Article Data: 30

Chemical Properties

• Boiling Point: 209℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.245
• Vapor Pressure: 0.047mmHg at 25°C
• Refractive Index: 1.41
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 12.73±0.10(Predicted)
• CAS DataBase Reference: Dimethyl hydroxymethylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl hydroxymethylphosphonate(24630-67-9)
• EPA Substance Registry System: Dimethyl hydroxymethylphosphonate(24630-67-9)

Safety Data

• Hazardous Substances Data: 24630-67-9(Hazardous Substances Data)

Usage

General Description

Dimethyl hydroxymethylphosphonate (CAS number: 762-04-9) is a crucial chemical widely used in the industry for various purposes. Primarily, it is used as a reagent in the synthesis of other chemicals, including certain pesticides, flame retardants, and additives in plastics. It is also used in the production of pharmaceutical drugs and specialty chemicals. Dimethyl hydroxymethylphosphonate appears as a clear, colorless liquid that is stable under ordinary conditions but can react with water or steam to produce heat and corrosive, toxic gases. It should be handled with care as it can cause skin and eye irritation, and severe exposure can lead to respiratory issues.

InChI:InChI=1/C3H9O4P/c1-6-8(5,3-4)7-2/h4H,3H2,1-2H3

Upstream product

• 756-79-6 dimethyl methane phosphonate 
• 50-00-0 formaldehyd 
• 762-04-9 phosphonic acid diethyl ester 
• 868-85-9 Dimethyl phosphite 
• 121-45-9 phosphorous acid trimethyl ester 
• 96-36-6 methyl phosphite 
• 69412-44-8 (dimethoxyphosphanyloxy-methyl)-phosphonic acid dimethyl ester 
• 76-05-1 trifluoroacetic acid 
• 24630-57-7 O,O-dimethylacetoxymethylphosphonate 

Downstream Products

• 34679-45-3 (2-Cyano-ethoxymethyl)-phosphonic acid dimethyl ester 
• 69054-01-9 (1-ethoxy-ethoxymethyl)-phosphonic acid dimethyl ester 
• 34679-47-5 3-(Dimethoxy-phosphorylmethoxy)-propionic acid methyl ester 
• 69412-44-8 (dimethoxyphosphanyloxy-methyl)-phosphonic acid dimethyl ester 
• 215655-75-7 (2,4-dichloro-phenoxy)-acetic acid dimethoxy-phosphorylmethyl ester 
• 852610-26-5 2-methyl-acrylic acid 2-(dimethoxy-phosphorylmethoxycarbonylamino)-ethyl ester 
• 27445-79-0 dimethyl formylphosphonate 
• 1208256-19-2 O,O-dimethyl-2,6-pyridinyldi(formyloxymethylphosphonate) 
• 1201795-29-0 methyl tosyloxymethanephosphonate 
• 80792-13-8 dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate 
• 1378531-66-8 dimethyl vinyloxymethylphosphonate 
• 1614827-32-5 O,O-dimethyl 1-((4,6-dichloropyrimidin-2-yl)carbamyloxy)methylphosphonate 
• 31618-90-3 diethyl (p-toluenesulfonyloxymethane)phosphonate 
• 76-05-1 trifluoroacetic acid 

Relevant articles and documents

Methyl 4-toluenesulfonyloxymethylphosphonate, a new and versatile reagent for the convenient synthesis of phosphonate-containing compounds

A straightforward procedure leading to the new phosphonylating reagent, methyl 4-toluenesulfonyloxymethylphosphonate, requiring no chromatographic purification is described. This stable reagent works with the same efficiency as dimethyl and other dialkyl esters for the introduction of an O-phosphonomethyl moiety while, in contrast to dimethyl ester, it does not cause any unwanted methylation of sensitive functionalities. Its utility for the alkylation of protected nucleosides in high yield is exemplified.

An efficient and simple strategy toward the synthesis of highly functionalized compounds

The expedient syntheses of small libraries of ((β-ethoxycarbonyl, -cyano and -acetyl)propyloxy) methylphosphonate scaffolds bearing olefin, sulfanyl, or amine functions are described. All these new derivatives are readily produced from easily available starting reagents (aldehydes, electron-poor olefins, and dialkylphosphites) following a three steps reaction sequence of condensations, SN2′-type reaction and a conjugated thia- or aza-Michael 1,4-addition with aromatic and aliphatic thiol or amine nucleophiles.

Melamine alkyl phosphate as well as preparation method and application thereof

The invention relates to melamine alkyl phosphate as well as a preparation method and application thereof, which mainly solves the problems that a common flame retardant generally cannot contain phosphorus and nitrogen elements at the same time and a preparation process of the flame retardant containing the phosphorus and nitrogen elements at the same time is complex in the prior art. Through providingmelamine alkyl phosphate, the preparation method comprises the following steps of adding methanol and 96% by mass of paraformaldehyde into a reaction vessel according to a molar ratio of (3-10):(1.5-5.0), adjusting the pH value to 9.5-11.5, depolymerizing paraformaldehyde, and adding dimethyl phosphite to react, thereby obtaining hydroxymethyl dimethyl phosphite, and reacting the partially etherified melamine resin with hydroxymethyl dimethyl phosphite according to the molar ratio of 1: (1-3) at the temperature of 80-100 DEG C, regulating the pH value to 8.5-9.5, and removing the solventto obtain the melamine alkyl phosphate and the application thereof, so that the problems are better solved, and the method can be applied to industrial application of polyurethane foam products.

HERBICIDAL COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.